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目的探讨中国人群中父母脑卒中史与子代脑卒中发病的关系。方法1992—1994年在全国12组人群中分别整群随机抽取1000～2000人进行心血管病危险因素调查,并对心血管事件的发生情况进行随访观察,随访至2005年6月,平均随访10.8年。结果15131例随访对象共发生脑卒中事件370例。在控制了年龄、性别后,父母双方均无脑卒中史者、仅父母一方有脑卒中史者、父母双方均有脑卒中史者发生脑卒中的相对危险分别为1.00、1.74(1.33～2.29)和3.61(1.86～7.01)。在进一步控制了基线时的吸烟、饮酒、总胆固醇、高密度脂蛋白胆固醇、空腹血糖、体重指数和收缩压后,上述各组发生脑卒中的相对危险分别为1.00、1.34(1.02～1.77)和2.50(1.29～4.87)。结论父母有脑卒中史者具有较高的发生脑卒中危险性,父母双方均有脑卒中者脑卒中发病危险的增加尤为显著。
Objective To explore the relationship between the parental stroke history and stroke in offspring in Chinese population. Methods A total of 1000 to 2000 people were randomly selected from 12 groups of people in China from 1992 to 1994 to investigate the risk factors of cardiovascular disease. The incidence of cardiovascular events was followed up until June 2005 with an average follow-up of 10.8 year. Results A total of 370 cases of stroke occurred in 15131 follow-up subjects. After controlling for age and gender, both parents had no history of stroke, only one parent had a history of stroke, and both parents had a history of stroke. The relative risks of stroke were 1.00 and 1.74 (1.33 to 2.29) And 3.61 (1.86 ~ 7.01) respectively. After further control of baseline smoking, alcohol consumption, total cholesterol, high-density lipoprotein cholesterol, fasting blood glucose, body mass index and systolic blood pressure, the relative risks of stroke in the above groups were 1.00, 1.34 (1.02-1.77) and 2.50 (1.29 ~ 4.87). Conclusions Parents with a history of stroke have a higher risk of developing stroke and the risk of stroke is significantly greater for both parents.