为了控制进入鼻腔的药液的容量,一般采取喷雾法或滴入法给药。药物在鼻腔内的沉积部位和清除速率可影响到鼻内给药的疗效。制剂在鼻腔内的沉积部位取决于药物释放系统的特性和给药方法。1976年Aoki等比较了较大量溶液以喷雾和滴入法给药时,在鼻腔内的沉积情况和清除率,指出滴入法药液在鼻腔内壁的复盖率较大,当给药量为0.1～0.75ml时也与给药量无关。两种给药 In order to control the volume of liquid into the nasal cavity, the general spray or drip method. Drugs in the nasal cavity of the deposition site and clearance rate can affect the efficacy of intranasal administration. The deposition site of the preparation in the nasal cavity depends on the nature of the drug delivery system and on the method of administration. In 1976 Aoki et al. Compared the deposition and clearance rate of nasal cavity when a large amount of solution was sprayed and instilled, and pointed out that the drip method solution has a larger coverage rate on the inner wall of the nasal cavity. When the dosage is 0.1 ~ 0.75ml also has nothing to do with the dose. Two kinds of medicine