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[目的]研究有机氯农药暴露与乳腺癌发生的关系。[方法]运用病例对照研究,收集177例乳腺疾病患者的血液(5ml)和脂肪组织(10g)标本,运用气相色谱仪检测病例组(乳腺癌患者)和对照组(乳腺良性疾病患者)血清和脂肪组织中的有机氯农药残留。[结果]患者的居住地在病例组和对照组之间有差异(χ2=4.70,P=0.03),将城市与农村患者分层。城市和农村患者,血清中β-HCH和PCTA暴露在病例组和对照组之间差异有统计学意义(P<0.001);脂肪组织中β-HCH、PCTA和PP′-DDE暴露在病例组和对照组之间亦差异有统计学意义(P<0.001)。血清和脂肪组织中,有机氯农药暴露增加乳腺癌的患病风险,OR值均大于2。[结论]有机氯农药暴露可能与乳腺癌的发生有关。
[Objective] To study the relationship between organochlorine pesticide exposure and breast cancer. [Methods] Blood samples (5ml) and adipose tissue (10g) from 177 patients with breast diseases were collected. A total of 177 breast cancer patients were collected from the patients with breast cancer and the control group (benign breast disease patients) by gas chromatography Organochlorine pesticide residues in adipose tissue. [Results] The patient’s place of residence was different between the case group and the control group (χ2 = 4.70, P = 0.03), stratifying urban and rural patients. In urban and rural areas, β-HCH and PCTA exposure in serum were significantly different between the case group and the control group (P <0.001); β-HCH, PCTA and PP’-DDE in the adipose tissue were significantly increased The difference between the control group was also statistically significant (P <0.001). In serum and adipose tissue, organochlorine pesticide exposure increased the risk of breast cancer, the OR values were greater than 2. [Conclusion] The exposure of organochlorine pesticides may be related to the occurrence of breast cancer.