糖尿病肾病是糖尿病的常见并发症,也是引起终末期肾病的最主要因素。其发生发展过程可能涉及多种机制,故需经多途径治疗。综述导致糖尿病肾病进展的可能机制及药物控制的可能途径,为进行基础研究、新药研发以及阻止糖尿病肾病的恶化提供依据。 Diabetic nephropathy is a common complication of diabetes, but also the most important cause of end-stage renal disease. Its occurrence and development process may involve a variety of mechanisms, it requires multi-channel treatment. The possible mechanisms leading to the progression of diabetic nephropathy and the possible ways of drug control are summarized, which provide the basis for basic research, research and development of new drugs and prevention of the worsening of diabetic nephropathy.