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目的：探讨谷氨酸及其 Ｎ Ｍ Ｄ Ａ 受体是否参与牙髓伤害性刺激的传递，揭示它们与牙痛传递的内在关系。方法：随机分配为４ 组的２８ 只大鼠。一组单纯给予穿髓刺激，另一组在穿髓刺激前预先侧脑室分别给予３ 种浓度的谷氨酸 Ｎ Ｍ Ｄ Ａ 受体拮抗剂 Ｍ Ｋ－ ８０１ 。另设 Ｍ Ｋ－ ８０１ 对照组和正常对照组。存活相同时间后观察各组动物延髓 Ｆｏｓ 蛋白的表达。结果： Ｍ Ｋ－ ８０１ ＋ 穿髓组较单纯穿髓组延髓 Ｆｏｓ 蛋白表达量显著减少，且呈剂量依赖性。结论：谷氨酸可能参与了牙髓伤害性信息的传递过程，其中 Ｎ Ｍ Ｄ Ａ 受体具有重要作用。
OBJECTIVE: To investigate whether glutamate and its N M D A receptors are involved in the transmission of nociceptive stimuli and to reveal their intrinsic relationship with the transmission of toothache. Methods: 28 rats were randomly assigned to 4 groups. One group was treated with transmyotrophic stimulation alone, while the other group was pre-transventricularly administered with three concentrations of glutamate NMDA receptor antagonist M K-801 before transmuscular stimulation. Another M K-801 control group and normal control group. After surviving the same time, the expression of Fos protein in the medulla oblongata of each group was observed. Results: The expression of Fos protein in medulla oblongata of M K-801 + group was significantly lower than that of M group, and dose dependent. CONCLUSION: Glutamate may be involved in the transmission of dental pulp nociceptive information, with N M D A receptor playing an important role.