类风湿性关节炎(RA)是关节的一种慢性、全身性、炎症性和破坏性疾病,发病时为关节内滑膜炎,经久不愈而导致滑膜增厚、血管翳形成、软骨及软骨下骨质破坏,最终关节发生畸形和强直。传统的RA药物治疗策略带有一定的局限性和弊端,因此,20世纪90年代以来,人们提出了新的治疗策略,并开发出一些新药。 Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory and devastating disease of the joint, which is caused by intra-articular synovitis at the time of onset, prolonged unhealed synovial thickening, angiogenesis, cartilage and Subchondral bone destruction, the final joint deformity and rigidity. Traditional RA drug treatment strategies have some limitations and drawbacks. Therefore, since the 1990s, new treatment strategies have been proposed and some new drugs have been developed.