目的；了解雌激素对马桑内酯（ＣＬ）致■大鼠中枢神经系统ＦＯＳ蛋白（ＦＯＳ）表达的影响。方法：应用流式细胞免疫荧光技术对ＣＬ致■及给予雌激素后再致■大鼠大脑皮层、海马细胞ＦＯＳ表达进行定量检测。结果：ＣＬ致■组大鼠大脑皮层、海马ＦＯＳ表达的荧光指数（ＦＩ）和阳性细胞数较正常对照组明显增高（Ｐ＜０．０１）；给予雌二醇（Ｅ２）后再致■组皮层、海马ＦＯＳ表达较单纯ＣＬ致■组增加（Ｐ＜００５，Ｐ＜０．０１）。结抡：由于ＦＯＳ可作为神经元兴奋的标志，雌激素可以提高皮层、海马神经细胞的兴奋性，提示雌激素有致■性。 Objective To investigate the effect of estrogen on the expression of FOS protein (FOS) in rat central nervous system induced by coronal lactone (CL). Methods: Flow cytometry was used to detect the FOS expression in the cortex and hippocampus of rats induced by CL and given estrogen. Results: The fluorescence index (FI) and positive cells of FOS in cerebral cortex and hippocampus in CL group were significantly higher than those in normal control group (P <0.01) The expression of FOS in cortex and hippocampus was higher than that in pure CL group (P <0.05, P <0.01). Results: As FOS neurons can be used as a sign of excitement, estrogen can increase the cortex, hippocampal nerve cell excitability, suggesting that estrogen has caused ■ ■.