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癌胚抗原（CEA）是一种肿瘤相关抗原,由Gold和Freeman于1965年首次提出。该抗原为一糖蛋白,β电泳测得其相对分子质量约为200 000,由一单链蛋白（约 800个氨基酸）及糖侧链组成,糖链部分占总相对分子质量的50％～80％。CEA首先被认为是结肠腺癌的一特异抗原。更新的研究表明,CEA存在于许多涉及胃肠或肺等来源于外胚层组织的癌细胞中。据有关报道,结肠粘膜分泌物中也有少量CEA,在非黄疸病人正常胆汁中有CEA类似物质。CEA检测对监测治疗后伴有血循环CEA持续升高的病人具有重要价值,高CEA浓度预示有潜伏的
Carcinoembryonic antigen (CEA) is a tumor-associated antigen first proposed by Gold and Freeman in 1965. The antigen is a glycoprotein and its relative molecular mass is about 200,000 measured by β electrophoresis. It consists of a single-chain protein (about 800 amino acids) and sugar side chains. The sugar chain part accounts for 50% to 80 of the total relative molecular mass. %. CEA is first thought to be a specific antigen for colon adenocarcinoma. Newer studies have shown that CEA is present in many cancer cells that are derived from epiblast tissue, such as gastrointestinal or lung. According to relevant reports, there is also a small amount of CEA in the colonic mucosal secretions, and there are CEA-like substances in normal bile of non-jaundiced patients. The CEA test is of great value for patients with persistent elevated blood circulation CEA after monitoring therapy. High CEA concentrations indicate potential