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2-巯基乙磺酸钠(Sodium 2-mercapto-ethanesulfonate;MESNA,HSCH_2CH_2SO_3Na)系活性巯基化合物。选择地存在于细菌、真菌、植物及某些动物组织中,为甲基转移酶的辅因子,也称为辅酶M,为甲烷杆菌属细菌产生甲烷所必需。早期曾用合成品作为粘液溶解剂及重金属解毒剂,用于祛痰、治疗慢性支气管炎(商品名Mistabron)及砷、汞等的解毒。近年发现该品对环磷酰胺类烷化剂的泌尿系毒性有优良的解毒作用,从而扩大了这类抗癌剂的临床应用。
Sodium 2-mercapto-ethanesulfonate (MESNA, HSCH_2CH_2SO_3Na) is an active thiol compound. Optionally present in bacteria, fungi, plants and certain animal tissues, is a cofactor for methyltransferase, also known as Coenzyme M, which is necessary for Methanobacterium to produce methane. Early use of synthetic products as a mucolytic agent and heavy metal antidote for expectorant treatment of chronic bronchitis (Mistabron) and arsenic, mercury detoxification. In recent years, the product was found to have excellent detoxification effects on the urinary toxicity of cyclophosphamide alkylating agents, thereby expanding the clinical application of such anticancer agents.