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本研究在胃、十二指肠慢性埋植应力传感器的大鼠上，观察了大鼠胃肠移行性复合运动（ＭＭＣ）的特点及西沙必利对ＭＭＣ的作用及与胃动素释放的关系。结果表明：（１）空腹时。大鼠胃、十二指肠可以记录到典型的ＭＭＣ活动。（２）西沙必利可增强ＭＭＣ收缩活动，分别使胃、十二指肠ＭＭＣⅢ相延长９３％和３５％。（３）西沙必利使胃肠ＭＭＣⅢ相时的血浆胃动素浓度升高。（４）给予抗胃动素血清、５－ＨＴ４受体拮抗剂及阿托品可抑制西沙必利对ＭＭＣ的收缩作用。上述结果提示：西沙必利增强胃肠收缩活动的作用机制．除通过肠神经系统５－ＨＴ，受体引起ＡＣｈ释放外，还通过激发胃动素的释放，使ＭＭＣⅢ相收缩增加。
In this study, gastric and duodenal chronic stress sensors were implanted in rats to observe the characteristics of gastrointestinal migrating compound exercise (MMC) in rats and the effect of cisapride on MMC and its relationship with the release of motilin . The results showed that: (1) fasting time. Rat stomach, duodenum can record the typical MMC activity. (2) cisapride can enhance MMC contraction activities, respectively, extend the stomach, duodenum MMC Ⅲ phase 93% and 35%. (3) Cisapride increased the concentration of plasma motilin in gastrointestinal MMCIII phase. (4) Anti-motilin serum, 5-HT4 receptor antagonist and atropine can inhibit cisapride contractile effect on MMC. The above results suggest that cisapride enhances the mechanism of gastrointestinal contractile activity. In addition to passing 5-HT through the enteric nervous system, the receptor causes ACh release, but also induces an increase in MMC III phase contraction by stimulating the release of motilin.