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目的观察甲亢平消汤联合小剂量他巴唑治疗格雷夫斯病的临床疗效并探讨其作用机制。方法将80例格雷夫斯病患者随机分为两组(各40例),治疗组给予甲亢平消汤联合小剂量他巴唑片治疗,对照组给予常规剂量他巴唑片治疗,疗程均为3个月。治疗后观察疗效及血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)和高灵敏促甲状腺素(hTSH)等指标变化。结果治疗后治疗组总有效率为95.00%,对照组总有效率为84.62%;两组比较有统计学意义(P<0.05)。治疗后两组血清FT3及FT4均明显下降,血清hTSH明显上升,差异有统计学意义(P<0.01);组间比较无统计学意义(P>0.05)。结论甲亢平消汤联合小剂量他巴唑治疗格雷夫斯病有较好的临床疗效,并可减少他巴唑用量。
Objective To observe the clinical efficacy of hyperthyroidism Pingxiao decoction combined with low-dose methbazole in the treatment of Graves’ disease and to explore its mechanism. Methods Eighty Graves’ patients were randomly divided into two groups (40 in each). The treatment group was given HQTD combined with low dose of itarzole tablets and the control group was treated with metocloprazole tablets. The course of treatment was 3 months. After treatment, the curative effect and the changes of serum free triiodothyronine (FT3), free thyroxine (FT4) and hypersensitive thyrotropin (hTSH) were observed. Results After treatment, the total effective rate was 95.00% in the treatment group and 84.62% in the control group. The two groups were statistically significant (P <0.05). After treatment, the serum levels of FT3 and FT4 in the two groups were significantly decreased, serum hTSH was significantly increased, the difference was statistically significant (P <0.01); there was no significant difference between the two groups (P> 0.05). Conclusion Jiakang Pingxiao Decoction combined with low-dose methbazole treatment of Graves disease has a better clinical efficacy, and can reduce the amount of methimazole.