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目的:调查生鱼胆中毒患者的临床特点。方法:收集2004年5月至2008年10月期间生鱼胆中毒住院患者的临床资料,分析患者的性别、年龄、服用生鱼胆的个数、中毒发生时间与症状、肝肾功能、心肌酶水平、治疗及转归。结果:共24例生鱼胆中毒患者,其中男性9例,女性15例,年龄8～65岁,平均年龄(26.9±3.4)岁。每人服用生鱼胆1～2个。服后2～72h,出现急性胃肠反应,其中15例伴急性肾衰竭[BUN(34.5±13.7)mmol/L,SCr(825±172)μmol/L],12例伴肝功能不全[ALT(958±523.5)U/L,AST(562.5±256.8)U/L],12例伴心肌损害[LDH(3423.4±101.5)U/L]。经血液灌注和血液透析治疗后患者恢复正常。结论:生鱼胆可致多脏器衰竭。血液灌注和血液透析联用是治疗生鱼胆中毒的有效措施。
Objective: To investigate the clinical features of raw fish gallbladder poisoning patients. Methods: The clinical data of hospitalized patients with raw fish gallbladder poisoning during May 2004 to October 2008 were collected. The patients’ gender, age, the number of raw fish taken, the time and symptoms of poisoning, liver and kidney function, Level, treatment and outcome. Results: A total of 24 cases of raw fish gallbladder poisoning, including 9 males and 15 females, aged 8 to 65 years, mean age (26.9 ± 3.4) years. Take 1 to 2 raw fish per person. Acute gastrointestinal reactions occurred in 2 to 72 hours after the operation, of which 15 cases had acute renal failure (BUN 34.5 ± 13.7 mmol / L, SCr 825 ± 172 μmol / L), and 12 patients had hepatic dysfunction [ALT 958 ± 523.5) U / L, AST (562.5 ± 256.8) U / L], and 12 patients with myocardial damage [LDH (3423.4 ± 101.5) U / L]. After hemoperfusion and hemodialysis patients returned to normal. Conclusion: Raw fish can cause multiple organ failure. Blood perfusion and hemodialysis combined with the effective measures for the treatment of raw fish poisoning.