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应用灰色理论研究格列吡嗪片剂在健康志愿者体内的药物动力学模型. 8名健康志愿者口服格列吡嗪片5 mg后,用HPLC法测定不同时间血清中血药浓度,并建立格列吡嗪片在体内的灰色药物力学模型.预测值与实测值的平均绝对误差E =0 .5 3 2 ,平均相对误差为1 .0 5 9% ;达峰时间tmax =2 .5 6h;达峰浓度Cmax=0 .3 85 8μg/ml;曲线下总面积AUC =2 .75 44(μg/ml) * hour.该灰色模型的建立为格列吡嗪片剂的临床合理化用药提供了理论依据.
The gray theory was used to study the pharmacokinetics model of glipizide in healthy volunteers. Eight healthy volunteers were given 5 mg oral glipizide tablets, and the plasma concentration of serum was determined by HPLC at different time. Gray drug mechanics model of glipizide tablets in vivo.The average absolute error of predicted value and measured value was E = 0.53 2, the average relative error was 1.059%; the peak time tmax was 2.56h ; Peak concentration C max = 0.385 8 μg / ml; Total area under the curve AUC = 2.75 44 (μg / ml) * hour. The establishment of this gray model provided a clinically rationalized drug for glipizide tablets Theoretical basis.