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在有机化学实验教科书中,芳核直接氯代实验甚少。为了训练大学生对于此类反应的操作,使之了解其实施方法,特介绍“2,4-二反应(1)所需的氯气,是由氯酸钠和盐酸作用产生的: 5Cl(?)+ClO_3(?)+6H(?)=3Cl_2↑+3H_2O 实验步骤一、2,4-二氯乙酰苯胺的制备在装有搅拌器、温度计、恒压滴液漏斗和球形冷凝器(末端装有引出室外或连接气体吸收装置的导气管)的250毫升四颈烧瓶中,倒入56毫升冰乙酸和46毫升浓盐酸,加入13.5克(0.1摩)乙酰苯胺。开动搅拌,稍加温热使其溶解。将烧瓶内容物冷却至0℃左右,然后滴加11.7克(0.11摩)氯酸钠于28
In the organic chemistry experiment textbook, there are very few direct chlorination experiments on aromatic nuclei. In order to train undergraduates to operate such reactions and to understand their methods of implementation, the chlorine required for the 2,4-bis reaction (1) is introduced by the action of sodium chlorate and hydrochloric acid: 5Cl (?) + ClO_3 (?) + 6H (?) = 3Cl_2 ↑ + 3H_2O Experimental procedure A 2,4-dichloroacetanilide Preparation equipped with a stirrer, thermometer, constant pressure dropping funnel and a spherical condenser (Or airway to which the gas absorption device was connected, either outdoors or connected), 56 ml of glacial acetic acid and 46 ml of concentrated hydrochloric acid were added and 13.5 g (0.1 mol) of acetanilide was added. Stirring was started and slightly warm to dissolve The contents of the flask were cooled to about 0 ° C and then 11.7 g (0.11 mole) sodium chlorate was added dropwise at 28