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The target compound(Z)-4-[3-(4-methyl-l,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acr-yloyl]morpholine was synthesized by the nucleophilic substitution,Horner-Emmons reaction,ester hydrolysis,and condensation.Its structure was characterized by NMR,H RMS and single-crystal X-ray diffraction.The crystal of the target compound belongs to monoclinic system,space group P21 with a = 11.5058(15),b = 6.6626(10),c =23.184(3)?,V = 1777.3(4)?3,Z = 8,Dc = 1.496 Mg/m3,F(000)= 792 and μ = 0.229 mm-1.X-ray analysis indicated C-H…O intermolecular H-bonds in this crystal structure.The target compound exhibited 53%curative activity against TMV.