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本文报道了下列实验结果:(1)从哥斯达黎加甲型肝炎病例用狨猴分离的CR326病毒,经狨猴传递四代,用来与8例甲型肝炎(临床自然感染5例,Ms-1病毒实验感染3例)、2例乙型肝炎(临床自然感染与Ms-2病毒实验感染各1例)的双份血清,在狨猴身上进行中和试验。血清转氨酶上升为诊断狨猴肝炎的指标,辅以病理学检查。试验结果表明,甲型肝炎病例全部产生了能中和CR 326病毒的抗体,而2例乙型肝炎则无此种抗体反应。
This article reports the following experimental results: (1) CR326 virus isolated from marmoset monkeys from Costa Rica and passaged through marmosets for four generations to be associated with 8 hepatitis A cases (5 cases of clinically natural infection, Ms-1 virus 3 cases of experimental infection) and 2 cases of hepatitis B (1 case of clinical natural infection and 1 case of Ms-2 virus infection). The neutralization test was conducted on the marmosets. Serum aminotransferase rose to diagnosis of marmoset hepatitis indicators, supplemented by pathological examination. The test results showed that all cases of hepatitis A produced antibodies capable of neutralizing CR 326 virus, whereas 2 cases of hepatitis B did not have such antibodies.