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目的了解本院健康体检者乙肝感染及转氨酶状况,针对性地进行健康管理,减少乙肝感染及预防肝功能的改变。方法采用酶联免疫吸附试验(ELISA)检测乙肝两对半及前S1抗原,同时采用速率法对体检者血清中ALT、AST进行检测,对乙肝感染者前S1阳性率与转氨酶异常的关联分析及男女感染者转氨酶(ALT、AST)异常进行统计。结果前S1阳性乙肝感染者转氨酶异常率与前S1阴性乙肝感染者转氨酶异常率有统计学意义(P<0.05);男女乙肝感染者转氨酶异常率间也有显著性差异(P<0.01)。结论前S1抗原与转氨酶异常呈较大相关性,男女感染者转氨酶改变差异有显著性。
Objective To understand the status of hepatitis B infection and transaminase in healthy physical examination in our hospital, to conduct targeted health management, reduce hepatitis B infection and prevent changes of liver function. Methods Serum ALT and AST were detected by enzyme linked immunosorbent assay (ELISA) in two pairs and a half of hepatitis B virus and pre-S1 antigen. Meanwhile, the relationship between the positive rate of pre-S1 and the abnormal transaminase in hepatitis B virus infection was analyzed. Male and female infected transaminase (ALT, AST) abnormalities statistics. Results The abnormal rate of transaminase in pre-S1 positive hepatitis B infection was significantly different from that in pre-S1 negative hepatitis B infection (P <0.05). There was also a significant difference (P <0.01) among the abnormal rates of transaminases in hepatitis B infection between men and women. Conclusions There is a significant correlation between pre-S1 antigen and aminotransferase abnormalities. The difference of transaminase between male and female infected patients is significant.