中国医学科学院基础医学研究所曾苹等,研究发现HPV的感染与宫颈癌的发生有密切关系。在已得到鉴定的60余型HPV中,16、18、33型等常在宫颈癌中检出,它们的E_6E_7两个开放读码框架及其表达产物在宫颈癌细胞中常被检出,且这两个阅读框架具有转化能力。E_6E_7基因的表达是否是宫颈癌发生及维持的必要条件,其特异性抑制宫颈癌细胞中E_6E_7的表达能否逆转宫颈癌细胞的恶性表 Institute of Basic Medical Sciences, Chinese Academy of Sciences, such as Tsang Ping, the study found that HPV infection and cervical cancer are closely related. Of the more than 60 types of HPV that have been identified, 16,18,33 and so on are often detected in cervical cancer, and their E_6E_7 two open reading frames and their expression products are often detected in cervical cancer cells, and this The two reading frames have the ability to transform. E_6E_7 gene expression is a necessary condition for the occurrence and maintenance of cervical cancer, and its specific inhibition of cervical cancer cells E_6E_7 expression can reverse the malignancy of cervical cancer cells