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分析了５种血清急相蛋白在２２例初治急性白血病患者的临床意义。结果表明：治疗前白血病患者Ｃ反应蛋白（ＣＲＰ），α＿１－酸性糖蛋白（α＿１－ＡＧ）明显高于正常（Ｐ＜０．００１）。α＿１－抗胰蛋白酶（α＿１－ＡＴ）、α＿２－巨球蛋白（α＿２－Ｍ）及β＿２－微球蛋白（β＿２－ＭＧ）与正常对照无差异（Ｐ＞０．０５）。白血病患者ＣＲＰ又明显高于非恶性血液病患者（Ｐ＜０．０１）。完全缓解后ＣＲＰ、α＿１－ＡＧ、α＿１－ＡＴ、β＿２－ＭＧ下降至正常，明显低于未缓解者。急相蛋白在未缓解者仍持续高于正常。α＿１－ＡＧ与α＿１－ＡＴ的水平与外周血白细胞数相关。认为血清急相蛋白特别是ＣＲＰ其次为α＿１－ＡＧ和α＿１ＡＴ对鉴别恶性与良性血液病有一定意义，动态观察能反映白血病细胞负荷及预测其治疗转归。
The clinical significance of 5 serum acute phase proteins in 22 newly diagnosed acute leukemia patients was analyzed. The results showed that C-reactive protein (CRP) and α_1-acid glycoprotein (α_1-AG) in patients with pre-treatment leukemia were significantly higher than those in normal controls (P <0.001). α_1-AT, α_2-M and β_2-MG were not different from the normal control (P> 0.05). CRP in leukemia patients was significantly higher than that in non-hematologic patients (P <0.01). CRP, α_1-AG, α_1 -AT, β_2-MG decreased to normal after complete remission, which were significantly lower than those without remission. Acute phase protein in people who did not remission continued to be higher than normal. The levels of α_1 -AG and α_1-AT were correlated with the number of peripheral leukocytes. It is considered that the serum acute phase proteins, especially CRP, followed by α_1 -AG and α_1AT are of certain significance in the differential diagnosis of malignant and benign blood diseases. Dynamic observation can reflect the load of leukemia cells and predict their outcome.