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目的检测胎儿生长受限(FGR)患者外周血中血管内皮生长因子(VEGF)的水平,并探讨其与FGR的关系。方法2002年1月至2004年1月汕头大学医学院第二附属医院应用双抗体酶联免疫吸附法(ELISA)检测晚期正常妊娠妇女(妊娠组,30例)以及FGR(FGR组,37例)母体外周血中VEGF的水平和脐血中的VEGF水平。结果(1)正常孕晚期母体外周血VEGF为(753±157)ng/L,新生儿脐血VEGF为(1074±343)ng/L;(2)FGR组母体外周血VEGF水平(424±137)ng/L,新生儿脐血VEGF水平为(745±243)ng/L。FGR组母体外周血和新生儿脐带血中VEGF均明显低于妊娠组孕晚期水平(P<0001)。结论妊娠晚期VEGF水平显著下降可能是FGR发病机制中的一个重要因素。
Objective To detect the level of vascular endothelial growth factor (VEGF) in peripheral blood of patients with FGR and to explore its relationship with FGR. Methods From January 2002 to January 2004, the patients with advanced normal pregnancy (pregnancy group, 30 cases) and FGR (FGR group, 37 cases) were detected by double antibody enzyme linked immunosorbent assay (ELISA) at the Second Affiliated Hospital of Medical College of Shantou University. The level of VEGF in maternal peripheral blood and the level of VEGF in cord blood. Results (1) VEGF levels in maternal peripheral blood in the third trimester of pregnancy were (753 ± 157) ng / L and (1074 ± 343) ng / L, respectively; (2) VEGF levels in the peripheral blood of the FGR group were 424 ± 137 ) ng / L, and neonatal cord blood VEGF level was (745 ± 243) ng / L. The levels of VEGF in the peripheral blood of the FGR group and cord blood of the newborn were significantly lower than those of the third trimester of pregnancy (P <0001). Conclusions The significant decrease of VEGF level in late pregnancy may be an important factor in the pathogenesis of FGR.