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目的观察CO2激光联合5-氨基酮戊酸(5-aminolevulinic acid,ALA)光动力疗法(Photodynamic therapy,PDT)治疗鲍温样丘疹病(Bowenoid Papulosis,BP)的临床疗效及不良反应。方法治疗组42例患者首先采用CO2激光治疗,继以ALA-PDT治疗;对照组28例患者单纯予以CO2激光治疗,每周治疗1次,共治疗4次。结果治疗组患者痊愈28例,显效9例,有效率为88.1%,复发3例,复发率10.7%;对照组患者痊愈13例,显效5例,有效率为67.9%,复发6例,复发率46.2%。两组之间有效率和复发率差异均有统计学意义(χ2=4.30,χ2=4.60,P<0.05)。治疗组与对照组均有轻度术后创面疼痛与水肿,15例合并创面感染,9例出现表浅瘢痕。结论 CO2激光联合ALA-PDT是治疗鲍温样丘疹病的一种安全、有效、无明显不良反应的新疗法。
Objective To observe the clinical effects and adverse reactions of CO2 laser combined with 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) on Bowenoid Papulosis (BP). Methods 42 patients in the treatment group were treated with CO2 laser followed by ALA-PDT; 28 patients in the control group were treated with CO2 laser only once a week for 4 times. Results In the treatment group, 28 cases were cured and the effective rate was 88.1%. The recurrence rate was 10.7% in 3 cases and 13 cases were cured in the control group. The effective rate was 67.9%, the recurrence rate was 6% 46.2%. The difference between the two groups was statistically significant (χ2 = 4.30, χ2 = 4.60, P <0.05). The treatment group and the control group had mild postoperative wound pain and edema, 15 cases with wound infection, and 9 cases with superficial scar. Conclusion CO2 laser combined with ALA-PDT is a safe, effective and non-adverse new treatment for Bowenoid papulosis.