论文部分内容阅读
目的对眼部给药系统及影响因素进行综述。方法查阅文献,总结近年来眼部给药系统的最新研究成果、影响眼部给药好坏的因素及提高眼用制剂作用效率的方法。结果眼部给药存在给药屏障,药物可分别经角膜途径和结膜途径发挥局部治疗作用和全身治疗作用。生理因素、药物理化性质及剂型因素均会对药物在眼部传递产生影响。结论通过加入渗透促进剂、改变药物的剂型及减少给药体积可有效提高眼用制剂作用效率。
Objective To summarize the ophthalmic drug delivery system and its influencing factors. Methods The literature was reviewed to summarize the latest research results of ocular drug delivery systems in recent years, the factors that affect the quality of ophthalmic administration and the methods to improve the efficiency of ophthalmic preparations. As a result, there was an administration barrier for ophthalmic administration, and the drug could exert local therapeutic effects and systemic therapeutic effects via the corneal and conjunctival routes respectively. Physiological factors, physicochemical properties and dosage form factors affect the delivery of drugs in the eye. Conclusion By adding penetration enhancers, changing the dosage form and decreasing the administration volume, the efficiency of ophthalmic preparations can be effectively improved.