曾有报告面颈部放射治疗后可发生垂体功能减退。本文报告2例鼻咽部和上颌窦肿瘤经外照射后发生此并发症。例1:45岁,男性。于1954年因患鼻咽癌,给予深部X线治疗。剂量是3000rad/25天。分4个斜的照射野,包括了蝶鞍部。并于5个月后重复了相同的疗程。8年后,出现了典型的垂体机能减退的临床表现:疲劳,畏寒,阳萎,体毛脱落及睾丸萎缩。头颅X线片正常。血清蛋白结合碘1.6微克/100毫升,尿促性腺激素<5.0小鼠单位/24小时,尿17-羟类固醇2.0毫克/24小时,用双吡啶异丙酮后只提高到3.2毫 There have been reports of hypopituitarism after radiotherapy of face and neck. This article reports 2 cases of nasopharyngeal and maxillary sinus tumors after external irradiation occurred in this complication. Example 1: 45 years old, male. In 1954 due to nasopharyngeal carcinoma, given deep X-ray treatment. The dosage is 3000 rad / 25 days. Divided into four oblique irradiation field, including the sella saddle. And after 5 months repeat the same course of treatment. Eight years later, the typical clinical manifestations of pituitary dysfunction developed: fatigue, chills, impotence, body hair loss and testicular atrophy. Skull X-ray film normal. Serum protein-bound iodine 1.6 micrograms / 100 ml, urinary gonadotropin <5.0 mouse units / 24 hours, urinary 17-hydroxysteroid 2.0 mg / 24 hours, with bipyridine is only increased to 3.2 ml