在无溶剂和无催化剂条件下,以芳香醛、2,2-亚丁基-1,3-二噁烷-4,6-二酮或2,2-亚戊基-1,3-二噁烷-4,6-二酮和尿素为原料,经三组分反应合成了12种二苯基-2,4-氧杂-8,10-氮杂螺[5.5]十一烷-1,5,9-三酮衍生物.反应无溶剂污染,反应条件温和,收率为49%~63%.此外,还讨论了反应速度与取代基的关系,探讨了可能的缩合反应机理,并应用~1H NMR、~(13)C NMR、IR及ESI-MS等技术手段确定了产品的结构. Under solvent-free and catalyst-free conditions, aromatic aldehydes, 2,2-butylene-1,3-dioxane-4,6-dione or 2,2-pentylene-1,3- -4,6-dione and urea as starting materials, twelve kinds of diphenyl-2,4-oxa-8,10-azaspiro [5.5] undecane- 9-triketone derivative.The reaction was solvent-free and the reaction conditions were mild.The yield was 49% -63% .In addition, the relationship between the reaction rate and the substituent was also discussed, and the possible condensation reaction mechanism was discussed, and ~ 1H NMR, ~ (13) C NMR, IR and ESI-MS and other technical means to determine the structure of the product.