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不久前,中国科学院大连化学物理研究所药用资源开发研究组葛广波、杨凌团队研发了一种全新的二肽基肽酶–IV(DPP–IV,CD26)高特异性荧光探针,并将其用于人血及组织中DPP–IV的活性检测以及活细胞和组织层面的目标酶功能成像研究,相关研究成果发表在Biosensors and Bioelectronics上。DPP–IV是哺乳动物体内分布的一种重要的丝氨酸水解酶,其参与体内多种生物活性多肽(如肠促胰岛素、神经肽、胃泌素释放肽、生长激素释放激素等)的水解进而导
Not long ago, Ge Guangbo and Yang Ling from the Research Group for Medicinal Resources Development, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, developed a new high-specificity dipeptidyl peptidase-IV (DPP-IV, CD26) For the detection of DPP-IV activity in human blood and tissues, as well as functional imaging of target enzymes on living cells and tissues, the results of which are published in Biosensors and Bioelectronics. DPP-IV is an important serine hydrolase distributed in mammals and is involved in the hydrolysis of many bioactive peptides in the body (such as incretin, neuropeptide, gastrin releasing peptide, growth hormone releasing hormone, etc.)