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作者应用改良的固相放射免疫法测定了116例系统性红斑狼疮(systemic lupus erythematosus(?)SLE)和有关的自身免疫性疾病患者的抗心脂抗体。43例有血小板减少史或进行此项研究时血小板是减少的,两次测定血小板数均低于100 × 10~9/L,继发性血小板减少不在此列。43例中36例 SLE,3例原发性Sj(?)gren 综合征,2例类风湿性关节炎,2例混合性结缔组织病。其中31例(72%)IgG 抗心脂抗体水平升高,19例(44%)IgM 抗心脂抗体升高。无血小板减少的73例中28例(38%)IgG 抗心脂抗体升高。在IgG 抗心脂抗体最高的20例中16例(80%)有血小板减少史;IgM 抗心脂抗体升高的19例中11例(55%)有血小板减少;17例 IgG 和 IgM 抗心脂抗体同时升高。结果显示这类疾病患者 IgG 或 IgM 抗心脂抗体的升高与血小板减少之间有显著差异。血小板减少是 SLE 的并发症;其机制尚不清楚。
The authors used an improved solid-phase radioimmunoassay to determine anti-lipid antibodies in 116 patients with systemic lupus erythematosus (?) SLE and related autoimmune diseases. Thirty-seven patients had a history of thrombocytopenia or reduced platelet count during the study. The number of platelets measured twice was less than 100 × 10 ~ 9 / L, with no secondary thrombocytopenia. Of the 43 patients, 36 were SLE, 3 were primary Sj? Gren syndrome, 2 were rheumatoid arthritis and 2 were mixed connective tissue disease. Eleven patients (72%) had elevated levels of anti-lipoidal antibodies to IgG, and 19 (44%) patients had elevated levels of anti-lipopeptide antibodies. Eleven of the 73 patients without thrombocytopenia had elevated IgG anti-lipoidal antibodies in 28 (38%) patients. Thrombocytopenia occurred in 16 (80%) of the 20 patients with the highest IgG anti-lipoidal antibody; thrombocytopenia occurred in 11 (55%) of the 19 patients with elevated IgM anti-lipoidal antibodies; 17 with IgG and IgM resistance Lipid antibodies rise at the same time. The results show that there is a significant difference between elevated IgG and IgM anti-lipid antibodies and thrombocytopenia in patients with such diseases. Thrombocytopenia is a complication of SLE; the mechanism is not clear.