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目的了解药品不良反应(ADR)发生的特点及规律,促进临床合理用药。方法 对2011年收集并上报的166例ADR报告,分别从患者性别及年龄、引发ADR的药品种类、给药途径、ADR涉及器官或系统及临床表现等方面进行统计、分析。结果上报的ADR中以静脉给药方式为主,占95.2%;以抗感染药最多,占71.1%;ADR最常见的临床表现为皮肤及其附件损害,占54.8%。结论应合理使用抗感染药物,深入宣传ADR监测对临床合理用药的重要意义,增强医务人员对ADR监测的责任意识,保障临床用药合理、安全、有效,避免ADR的重复发生。
Objective To understand the characteristics and rules of adverse drug reaction (ADR) and to promote rational drug use in clinic. Methods A total of 166 ADR cases collected and reported in 2011 were statistically analyzed from the patient’s gender and age, the type of drug causing ADR, the route of administration, organs or systemic and clinical manifestations related to ADR. The results reported mainly in the intravenous administration of ADR, accounting for 95.2%; with the most anti-infectives, accounting for 71.1%; ADR most common clinical manifestations of damage to the skin and its accessories, accounting for 54.8%. Conclusion Anti-infectives should be rationally used to further publicize the significance of ADR monitoring in clinical rational use of drugs and enhance medical staff’s sense of responsibility for ADR monitoring so as to ensure that clinical medication is reasonable, safe and effective and avoid the repetitive occurrence of ADR.