长爪沙鼠实验性肝阿米巴病的特点为局部增生性脓肿、肝淋巴结病和脾肿大,但在人肝阿米巴病时,脾肿大却少见。而淋巴结和脾在细胞免疫的产生和体液免疫应答中有重要意义,如发生紊乱则将改变其对感染的应答。本文旨在观察长爪沙鼠在肝阿米巴脓肿发生过程中和注射阿米巴浸出液时抗体的产生和肝淋巴结、脾的组织改变。 Meriones unguiculatus is characterized by local proliferative abscesses, hepatic lymphadenopathy and splenomegaly, but splenomegaly is uncommon in human hepatomuscular disease. The lymph nodes and spleen in the generation of cellular immunity and humoral immune response is important, if the disorder will change its response to infection. This article aims to observe the Mongolian gerbils in the occurrence of hepatic amoebiasis abscess and amoeba extract the antibody production and liver lymph node, spleen tissue changes.