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六十年代Sharp等发现一些患者兼有系统性红斑狼疮（SLE）、硬化症（PSS）或多发性肌炎（PM）的临床表现、伴有高滴度抗nRNP抗体。1972年Sharp正式命名为混合结缔组织病（MCTD）。我院近一年使用血浆置换法治疗MCTD5例，现报告如下。材料与方法一、临床资料MCTD患者女性4例，男
In the 1960s, Sharp et al. Found that some patients had both clinical manifestations of systemic lupus erythematosus (SLE), sclerosis (PSS) or polymyositis (PM) accompanied by high titers of anti-nRNP antibodies. Sharp in 1972 formally named mixed connective tissue disease (MCTD). Nearly one year my hospital using plasmapheresis treatment of MCTD5 cases, are as follows. Materials and Methods First, the clinical data of 4 women with MCTD patients, male