[目的]筛选出具有全新结构的截短侧耳素类衍生物。[方法]从数据库中调出该类化合物相关的蛋白质或核苷酸受体,通过Autodocking模拟软件对其活性进行模拟。[结果]筛选出苗头化合物截短侧耳素水杨酰正丁胺醚,并对其合成反应工艺条件进行了初步探索,测试了其抗菌活性。[结论]以截短侧耳素、水杨酸为起始原料,经过酯化、胺酯交换、相转移反应合成出该化合物,该化合物具有一定抗菌作用,有进一步研究的价值。 [Objective] The research aimed to screen pleuromutilin derivatives with new structure. [Method] The proteins or nucleotide receptors related to these compounds were extracted from the database and their activities were simulated by Autodocking simulation software. [Result] The new compound, Pleuromutilin n-Butylamine, was screened out. The technological conditions of its synthesis reaction were explored. The antibacterial activity was tested. [Conclusion] The compound was synthesized by esterification, transesterification and phase transfer reaction with pleuromutilin and salicylic acid as starting materials. The compound has certain antibacterial activity and has the value of further research.