目的:探讨不同浓度七氟烷对患儿全麻诱导期癫痫样放电的影响。方法:选择择期全麻下行扁桃体和/或腺样体摘除术患儿66例，年龄3～12岁，ASA分级Ⅰ或Ⅱ级，性别不限，采用随机数字表法分为4%七氟烷组(L组)、6%七氟烷组(M组)和8%七氟烷组(H组)，每组22例。术中采用全凭静脉麻醉。记录诱导期癫痫样放电和苏醒期谵妄的发生情况。采用n χ2检验对癫痫样放电与苏醒期谵妄进行相关性分析。n 结果:与L组比较，H组兴奋型癫痫样放电发生率降低，M组和H组癫痫样放电发生率降低(n P0.05)；3组抑制型癫痫样放电和苏醒期谵妄发生率差异无统计学意义(n P>0.05)。癫痫样放电、兴奋型癫痫样放电的发生与苏醒期谵妄的发生具有相关性(n P0.05)。n 结论:低浓度(4%)七氟烷可导致患儿全麻诱导期兴奋型癫痫样放电增加。“,”Objective:To investigate the effects of sevoflurane at different concentrations on epileptic discharge during general anesthesia induction in children.Methods:Sixty-six pediatric patients of both sexes, aged 3-12 yr, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, undergoing elective tonsillectomy or (and) adenoidectomy under general anesthesia, were divided into 3 groups (n n=22 each) using a random number table method: 4% sevoflurane group (L group), 6% sevoflurane group (M group) and 8% sevoflurane group (H group). Combined intravenous-inhalational anesthesia was used during operation.The occurrence of epileptiform discharge during induction period and delirium during emergence was recorded.The correlation between epileptiform discharge and delirium during emergence was analyzed using n χ2 test.n Results:Compared with group L, the incidence of excitatory epileptiform discharge was significantly decreased in group H, and the incidence of epileptiform discharge was significantly reduced in group M and group H (n P0.05). There was no significant difference in the incidence of inhibitory epileptiform discharge and delirium during emergence among the three groups (n P>0.05). The occurrence of epileptiform discharges and excitatory epileptiform discharges was correlated with the occurrence of delirium during emergence (n P0.05).n Conclusion:Low concentration (4%) of sevoflurane can lead to an increase in excitatory epileptiform discharges during emergence from general anesthesia in children.