目的:探索补肾、健脾、活血三类中药复方对免疫因子引起下丘脑—垂体—肾上腺皮质轴反应状态的不同影响。方法:采用侧脑室注射白细胞介素—1β(IL—1β),观察大鼠下丘脑单胺类神经递质、血浆促肾上腺皮质激素(ACTH)、皮质酮(CORT)的含量,建立下丘脑—垂体—肾上腺皮质轴对免疫因子的反应状态,以此来观察三类中药对这一反应状态是否有不同的影响。结果:侧脑室内注射IL—1β能使下丘脑去甲肾上腺素(NE)含量明显下降;血浆ACTH、CORT浓度明显升高,与国外文献报道相似。补肾的右归饮能使因侧脑室注射IL—1β而降低的下丘脑NE含量进一步降低、能使升高的血浆ACTH、CORT含量进一步明显升高;健脾的四君子汤也有这一作用趋势;活血的桃红四物汤则无明显差异。结论:补肾中药能提高机体下丘脑—垂体—肾上腺皮质轴对免疫因子的反应性或反应能力,活血中药则无这一作用。 OBJECTIVE: To explore the different effects of three kinds of traditional Chinese herbal formulas for tonifying the kidney, invigorating the spleen, and promoting blood circulation on the response of the hypothalamus-pituitary-adrenocortical axis caused by immune factors. METHODS: Intracerebroventricular injection of interleukin-1β (IL-1β) was used to observe hypothalamic monoamine neurotransmitters, plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels in rats to establish the hypothalamus. The response status of the pituitary-adrenocortical axis to immune factors was used to observe whether the three types of Chinese medicine had different effects on this reaction state. RESULTS: Intracerebroventricular injection of IL-1β could significantly reduce the content of noradrenaline (NE) in the hypothalamus; the concentrations of ACTH and CORT in plasma increased significantly, similar to those reported in foreign literature. Kidney-nourishing Youguiyin can further reduce the content of hypothalamic NE which is reduced by lateral cerebral ventricle injection of IL-1β, and can increase the plasma ACTH and CORT levels further; the spleen’s Sijunzitang also has this tendency; There was no significant difference in blood-red peach soup. Conclusion: Bushen Chinese medicine can improve the reactivity or response of the hypothalamus-pituitary-adrenocortical axis of the body to immune factors, while the traditional Chinese medicine for activating blood has no such effect.