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选取卵巢上皮癌４０例、宫颈癌１３例、宫内膜癌１３例、良性肿瘤５０例和正常健康妇女５０例，以探讨卵巢上皮细胞癌膜抗原（ＣＡ１２５）、乳酸脱氢酶（ＬＤＨ）及同工酶、Ｃ－反应蛋白（ＣＲ）、唾液酸（ＳＡ）辅助诊断卵巢上皮癌的意义。结果：正常组血清ＣＡ１２５值（４×１０３±１．７６×１０３ｕ／Ｌ）及良性肿瘤组ＣＡ１２５值（１５×１０３±８．２４×１０３ｕ／Ｌ）明显低于卵巢癌组（２８０×１０３±７５×１０３ｕ／Ｌ）（Ｐ＜０．０５）；ＣＡ１２５辅助诊断卵巢上皮癌的敏感性（ＳＳ）为９５％、阳性拟然比（ＰＬＲ）为４．７５、准确性（ＡＣ）为８６％，明显高于宫颈癌的ＳＳ（８５％）、ＰＬＲ（４．２５）、ＡＣ（８０％）及宫内膜癌的ＳＳ（７７％）、ＰＬＲ（３．８５）、ＡＣ（７９％）。Ⅲ、Ⅳ期卵巢癌的ＣＡ１２５值（３９０×１０３±８２×１０３ｕ／Ｌ）明显高于Ⅰ、Ⅱ期卵巢癌的ＣＡ１２５值（２１０×１０３±７５×１０３ｕ／Ｌ）（Ｐ＜０．０５）；ＣＡ１２５的ＳＳ、ＮＰＶ、ＡＣ明显高于ＬＤＨ、ＣＲ、ＳＡ、ＣＲ的ＳＳ、ＮＰＶ、ＡＣ（Ｐ＜０．０５）；ＣＡ１２５的ＳＳ明显高于ＬＤＨ同功酶的ＳＳ７７％（Ｐ＜０．０５）。结论：ＣＡ１２５辅助诊断卵巢上
40 cases of ovarian epithelial carcinoma, 13 cases of cervical cancer, 13 cases of endometrial carcinoma, 50 cases of benign tumors and 50 cases of normal healthy women were selected to investigate the expression of epithelial ovarian cancer cell membrane antigen (CA125), lactate dehydrogenase (LDH) and Isoenzymes, C-reactive protein (CR), sialic acid (SA) in the diagnosis of epithelial ovarian cancer significance. Results: Serum CA125 levels (4 × 103 ± 1.76 × 103u / L) and CA125 values (15 × 103 ± 8.24 × 103u / L) in benign tumors were significantly lower in the normal group than those in the ovarian cancer group (280 × 103 ± 75 × 103u / L) (P <0.05). The sensitivity (CA) of CA125 in the diagnosis of epithelial ovarian cancer was 95%, the PLR was 4.75 and the accuracy was 86% , Significantly higher than SS (85%), PLR (4.25), AC (80%) and SS (77%), PLR (3.85%) and AC (79%) of cervical cancer. The CA125 values of stage Ⅲ and stage Ⅳ ovarian cancer (390 × 103 ± 82 × 103u / L) were significantly higher than those of stage Ⅰ and Ⅱ ovarian cancer (210 × 103 ± 75 × 103u / L) (P0.05) The SS, NPV and AC of CA125 were significantly higher than those of SS, NPV and AC of LDH, CR, SA and CR (P <0.05). The SS of CA125 was significantly higher than SS77% of LDH isoenzyme (P <0.05). 05). Conclusion: CA125 assists in diagnosis of ovary