目的 :探讨微电极记录技术在帕金森病外科治疗中的作用。方法 :采用微电极电生理记录技术监测术中靶点 ,对帕金森病 31例进行手术治疗 ,其中苍白球毁损术 14例、丘脑毁损术 6例、深部脑电刺激术 11例。结果 :最终毁损靶点较MR定位靶点位置更换率为 80 6 % ,手术效果优良 ,有效率 10 0 % ,原有症状术后改善率达 87 1% ,无永久并发症。结论 :微电极记录技术的应用能显著提高定位精度 ,减少并发症和提高手术效果 Objective: To investigate the role of microelectrode recording in the surgical treatment of Parkinson’s disease. Methods: The intraoperative target was monitored by microelectrode electrophysiological recording technique. Thirty-one cases of Parkinson’s disease were treated by surgery, including 14 cases of pallidotomy, 6 cases of thalamic damage and 11 cases of deep brain stimulation. Results: The target replacement rate was 80 6% compared with that of MR target. The operative effect was excellent and the effective rate was 100%. The original postoperative improvement rate was 87.1%. There was no permanent complication. Conclusion: The application of microelectrode recording technology can significantly improve the positioning accuracy, reduce complications and improve the surgical results