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目的:在夏天室温(20～30℃)、冷藏(4～8℃)和冷冻(-18～-20℃)等3种条件下,考察冬病夏治膏药的稳定性。方法:采用HPLC法测定上述三种条件下保存10,30,60,90 d后冬病夏治膏药中芥子碱硫氰酸盐的含量变化。结果:在夏天室温条件下,10 d后有效成分芥子碱硫氰酸盐从100%下降至27.5%;在冷藏条件下,10 d后有效成分芥子碱硫氰酸盐从100%下降至88.79%;在冷冻条件下,90 d后有效成分芥子碱硫氰酸盐从100%下降至97.35%。结论:冬病夏治膏药的最佳保存方法为冷冻贮藏。
OBJECTIVE: To investigate the stability of Xiazhi Xiazhi plaster under the following three conditions: room temperature (20-30 ℃), refrigeration (4-8 ℃) and freezing (-18-20 ℃) in summer. Methods: The content of sinapine thiocyanate in Dongzhi Xiazhi plaster after 10, 30, 60 and 90 days storage under the above three conditions was determined by HPLC. Results: Under the condition of room temperature in summer, the content of the active ingredient mustard alkali thiocyanate reduced from 100% to 27.5% after 10 days. Under the refrigerated condition, the content of the active ingredient mustard alkali thiocyanate reduced from 100% to 88.79% ; After freezing for 90 days, the active ingredient mustardine thiocyanate decreased from 100% to 97.35%. Conclusion: The best method to preserve winter plaster in summer is frozen storage.