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缺血一定时间的心肌恢复灌流后,组织损伤反而进行性加重,出现缺血心肌的再灌注损伤(reperfusion injury),其发病机制还不清楚,目前尚缺少有效的防治措施。大量研究表明,心肌缺血-再灌注损伤与缺氧-复氧损伤(oxygen paradox)、缺钙-复钙损伤(calcium paradox)有相似的病理表现和发病机制,推测分子氧和钙离子在缺血-再灌注损伤的发病过程中起着重要的作用。金属硫蛋白(metallothionein,MT)是生物机体内含有多量硫和金属的非酶蛋
Myocardial ischemia and reperfusion injury after a certain period of time, the tissue damage instead progresses aggravating ischemia reperfusion injury (reperfusion injury), the pathogenesis is unclear, there is still no effective prevention and treatment measures. A large number of studies have shown that myocardial ischemia-reperfusion injury and hypoxia - reoxygenation injury (oxygen paradox), calcium-calcium injury (calcium paradox) have a similar pathology and pathogenesis, suggesting that molecular oxygen and calcium in the absence of Blood-reperfusion injury plays an important role in the pathogenesis. Metallothionein (MT) is a kind of non-enzyme egg containing many sulfur and metal in biological body