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研究白藜芦醇对大鼠血清指标及肝指数的影响,探讨白藜芦醇对肝损伤大鼠的保护作用.将72只雄性大鼠随机分为6组,空白对照组、模型对照组、低、中、高剂量组和阳性药物对照组.连续给药30 d后称取大鼠重量,取血清分别检测血清谷草转氨酶(AST)、谷丙转氨酶(ALT)和超氧化物歧化酶(SOD)、丙二醛(MDA)含量,并测定肝指数、肾指数、脾指数.结果表明,白藜芦醇能降低大鼠血清中ALT、AST、TG的水平(P<0.05),提高了SOD的含量、降低了MDA的含量(P<0.05).说明白藜芦醇具有降低大鼠ALT、AST的作用,对肝损伤大鼠具有肝保护作用.
To investigate the effect of resveratrol on serum and hepatic index in rats, and to investigate the protective effect of resveratrol on hepatic injury in rats. 72 male rats were randomly divided into 6 groups, blank control group, model control group, The rats in the low, medium and high dose group and the positive drug control group were weighed for 30 days after continuous administration. Serum concentrations of AST, ALT and SOD were measured. ), Malondialdehyde (MDA) content, and determination of liver index, kidney index, spleen index. The results show that resveratrol can reduce the serum ALT, AST, TG levels (P <0.05), improve the SOD The content of MDA decreased (P<0.05). It showed that resveratrol had the effect of reducing ALT and AST in rats, and had liver protective effect on liver injury rats.