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测量了64例肾移植患者移植前后的骨矿含量及骨钙素(BGP)、甲状旁腺激素(PTH)、血液生化的变化,以探讨它们的相互关系及临床意义。结果术前血肌酐(SCr)、尿素氮(BUN)、磷(P)、PTH、BGP为高水平,血钙(Ca)低,骨矿含量(0.777±0.015g/cm2)明显低于对照组(0.811±0.035g/cm2)。术后肾功能正常者,SCr、BUN、Ca、P及PTH、BGP均恢复正常,骨矿含量半年后恢复至对照组水平。提示慢性肾功能衰竭及血液透析期间存在明显钙磷代谢异常,严重骨营养不良;肾移植成功后骨矿含量恢复,纠正了肾性骨病;肾移植后骨矿含量低者,往往提示预后不良。
The bone mineral content, BGP, PTH and blood biochemical changes in 64 renal transplant recipients before and after transplantation were measured to explore their correlation and clinical significance. Results The preoperative serum creatinine (SCr), blood urea nitrogen (BUN), phosphorus (P), PTH and BGP were high, and the blood calcium was low. The bone mineral content (0.777 ± 0.015g / cm2) In the control group (0.811 ± 0.035g / cm2). Normal postoperative renal function, SCr, BUN, Ca, P and PTH, BGP returned to normal, bone mineral content returned to the control group after six months. Prompted chronic renal failure and hemodialysis during the existence of obvious abnormal calcium and phosphorus metabolism, severe bone malnutrition; bone graft recovery after renal transplantation to correct the disease of the kidney; lower bone mineral content after kidney transplantation, often prompted a poor prognosis .