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目的探讨65岁以上老年乳腺癌的临床病理特点。方法对株洲市一医院病理科116例65岁以上的老年乳腺癌患者资料进行回顾性分析。分析老年乳腺癌肿块大小、组织学分级、淋巴结转移情况、雌激素受体(ER)、孕酮受体(PR)表达及人表皮生长因子受体2(C-erbB-2)、p53、谷胱甘肽S转移酶π(GSTπ)表达的特点,并与同期115例非老年患者比较。结果①老年乳腺癌肿块大小与非老年组比较,差异无统计学意义(P>0.05)。②老年组与非老年组乳腺癌淋巴结转移率比较差异有统计学意义(P<0.05)。③老年组与非老年组乳腺癌ER、PR、C-erbB-2的表达差异有统计学意义(P<0.05)。老年组ER、PR阳性表达率高,C-erbB-2阴性表达率高。老年组与非老年组乳腺癌p53、GSTπ的表达差异无统计学意义(P>0.05)。④非老年组Ⅲ级(组织学分级)患者比例高于老年组,老年组Ⅰ级患者比例高于非老年组。二组比较差异有统计学意义(P<0.05)。结论老年乳腺癌患者腋窝淋巴结转移率较低,组织学分级较低,ER、PR阳性表达率高,C-erbB-2阴性表达率高。
Objective To investigate the clinicopathological features of breast cancer over 65 years old. Methods A retrospective analysis was performed on the data of 116 elderly patients with breast cancer over 116 years of age from a hospital in Zhuzhou City. The size, histological grade, lymph node metastasis, expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (C-erbB-2) Glutathione S transferase π (GSTπ) expression characteristics, and with the same period in 115 cases of non-elderly patients. Results ① There was no significant difference in the size of breast cancer between the elderly and the non-elderly group (P> 0.05). ② There was significant difference in the lymph node metastasis rate between the elderly group and the non-elderly group (P <0.05). ③ The expression of ER, PR and C-erbB-2 in breast cancer in the elderly group and non-elderly group were significantly different (P <0.05). The elderly group ER, PR positive expression rate, C-erbB-2 negative expression rate. There was no significant difference in the expression of p53 and GSTπ between the elderly group and the non-elderly group (P> 0.05). ④ The proportion of grade Ⅲ (histological grade) patients in non-elderly group was higher than that in elderly group, and the proportion of grade Ⅰ patients in elderly group was higher than that in non-elderly group. The difference between the two groups was statistically significant (P <0.05). CONCLUSION: Older breast cancer patients have lower rates of axillary lymph node metastasis, lower histological grade, high expression of ER and PR, and high expression of C-erbB-2.