目的掌握河南省40年来百日咳的流行病学特征及其影响因素,为制定免疫策略和预测疫情趋势提供依据。方法对河南省不同免疫阶段的百日咳流行病学特征进行分析。结果河南省40年来共报告百日咳3 065 075例,死亡572例。大致可分4个阶段:1963~1978年,年平均发病率为293.47/10万,死亡43例;1979~1983年,年发病率为87.70/10万~17.78/10万,呈逐年下降趋势,死亡6例;1984~1990年,发病率为1.28/10万~6.73/10万,死亡1例;1990年以后发病率为0.25/10万~1.00/10万,连续10年无死亡病例。表明随着百日咳疫苗接种率的不断提高,不但大大降低了百日咳的发病率和死亡率,也改变了其流行周期。结论目前的免疫策略首先应继续做好儿童常规免疫,其次应加强百日咳疫情管理,提高疫情报告的及时性、准确性。 Objective To grasp the epidemiological characteristics of pertussis in Henan Province during the past 40 years and its influential factors, and to provide the basis for formulating immunization strategies and predicting the epidemic trend. Methods The epidemiological characteristics of pertussis in different stages of immunization in Henan Province were analyzed. Results Over 40 years, 3 065 075 cases of pertussis were reported in Henan Province, 572 deaths. It can be roughly divided into four stages: from 1963 to 1978, the average annual incidence was 293.47 / 100 000 and death was 43 cases. From 1979 to 1983, the annual incidence was 87.70 / 100000-17.17 / 100000, showing a declining trend year by year, 6 cases died; 1984 to 1990, the incidence was 1.28 / 100000 ~ 6.73 / 100000, 1 died; morbidity after 1990 0.25 / 100,000 ~ 1.00 / 10 million, for 10 consecutive years without deaths. Indicating that with the continuous increase of pertussis vaccination rate, not only greatly reduce the incidence and mortality of whooping cough, also changed its epidemic cycle. Conclusion The current immunization strategy should continue to do routine immunization of children, followed by strengthening the management of pertussis epidemic and improve the timeliness and accuracy of the epidemic report.