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本实验通过大鼠脊髓损伤模型,观察了抗氧化剂对组织和血清丙二醛(MDA)的影响。结果表明:大鼠脊髓损伤2h 后,损伤组织中 MDA 含量已明显高于对照组(P<0.05),3d 后增高更著(P<0.01);血清 MDA 在损伤2h 后已极明显高于对照组(P<0.01),以后逐渐降低。维生素 E、超氧化物歧化酶、过氧化氢酶及二甲基亚砜均能显著降低损伤组织 MDA(P<0.01)和血清 MDA(P<0.05)。提示脊髓损伤后组织脂质过氧化反应增强,早期应用抗氧化剂,可作为减轻继发损害的一项有效治疗。
In this study, the rat model of spinal cord injury was used to observe the effects of antioxidants on the tissue and serum malondialdehyde (MDA). The results showed that the content of MDA in the injured tissue was significantly higher than that in the control group (P <0.05) after 2h of spinal cord injury, and increased significantly after 3d (P <0.01) Group (P <0.01), then gradually decreased. Vitamin E, superoxide dismutase, catalase and dimethyl sulfoxide significantly decreased the MDA content in serum (P <0.01) and MDA in serum (P <0.05). It suggested that the tissue lipid peroxidation increased after spinal cord injury, and the early application of antioxidants could be used as an effective treatment to reduce secondary damage.