【摘 要】
：
目的 分析肝癌患者血清胎球蛋白A(fetuin A,AHSG)、核因子-κB(nuclear factor-κB,NF-κB)水平与经导管动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)术后预后的关系.方法 选取2014年5月～2016年4月在邯郸市中心医院普外科就诊并行TACE的85例肝癌患者为肝癌组,同期选取85例医院体检结果正常者为对照组.酶联免疫吸附试验法(enzyme linked immunosorbent assay,ELISA)检测
【机 构】
：
邯郸市中心医院介入科,河北邯郸 056000;邯郸市中心医院普外科,河北邯郸 056000
论文部分内容阅读
目的 分析肝癌患者血清胎球蛋白A(fetuin A,AHSG)、核因子-κB(nuclear factor-κB,NF-κB)水平与经导管动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)术后预后的关系.方法 选取2014年5月～2016年4月在邯郸市中心医院普外科就诊并行TACE的85例肝癌患者为肝癌组,同期选取85例医院体检结果正常者为对照组.酶联免疫吸附试验法(enzyme linked immunosorbent assay,ELISA)检测肝癌组患者行TACE治疗前与对照组体检当日血清AHSG和NF-κB水平;对肝癌患者TACE术后进行为期5年的随访,记录患者生存情况;分析肝癌患者血清AHSG和NF-κB水平的相关性以及二者与临床病理特征的关系;Kaplan-Meier法分析肝癌患者血清AHSG和NF-κB水平与TACE术后预后的关系;COX回归分析影响肝癌患者TACE术后预后不良的危险因素.结果 与对照组比较,肝癌组患者血清AHSG(14.57±3.69 ng/ml vs 5.29±1.34 ng/ml)和NF-κB(5.42±1.46 ng/ml vs 1.28±0.53 ng/ml)水平显著升高,差异均有统计学意义(t=21.794,24.574,均P=0.000);肝癌患者血清AHSG与NF-κB水平呈正相关(r=0.495,P=0.000);肝癌患者血清AHSG和NF-κB水平与AST水平、Child-Pugh分级、TNM分期有关(χ2=7.051～17.285,均P<0.05);AHSG高表达组患者5年累积生存率低于AHSG低表达组[17.78％(8/45)vs 40.00％(16/40)],NF-κB高表达组5年累积生存率低于NF-κB低表达组[19.15％(9/47)vs 39.47％(15/38)],差异均有统计学意义(χ2=5.161,P=0.023;χ2=4.284,P=0.038);TNM分期高及血清AHSG和NF-κB高表达是影响肝癌患者TACE术后预后不良的危险因素(P=0.002,0.001,0.000).结论 肝癌患者血清AHSG和NF-κB水平均呈高表达,二者与肝癌患者TACE术后预后密切相关,可作为预测TACE术后预后的潜在生物标志物.
其他文献
目的 分析系统性红斑狼疮(systemic lupus erythematosus,SLE)病人血清中IL-1家族细胞因子、拮抗剂与可溶性受体含量变化与临床价值.方法 选取泸州市中医医院于2018年6月～2020年6月期间收治的60例SLE病人为观察组,同期60例健康体检人员为对照组,另基于SLE疾病活动指数评分(SLEDAI),划分观察组为活动组和稳定组.对比上述三组IL-1家族细胞因子、拮抗剂、可溶性受体含量,并对SLE患者细胞因子水平与免疫指标ds-DNA,补体C3,C4,C1q的相关性进行分析.结
目的 探究宫颈癌患者血清脂质运载蛋白2(lipocalin 2,LCN2)水平,分析其与高危型人乳头瘤病毒(high risk-human papilloma virus,HR-HPV)病毒载量及临床分期的相关性.方法 选取2019年4月～2021年2月淮安市妇幼保健院收治的宫颈癌患者64例为研究对象(宫颈癌组),另选取同期治疗的宫颈上皮内瘤变患者60例(宫颈上皮内瘤变组)和体检健康女性69例(正常对照组).采用第二代杂交捕获技术(hybrid captureⅡ,HC-Ⅱ)进行HR-HPV病毒载量检测,采
目的 通过检测肝癌组织中泛素结合酶E 2T(ubiquitin binding enzyme E2T,UBE2T)表达,探究其对肝癌细胞增殖、克隆形成及细胞周期的影响及其潜在分子机制.方法 采用实时荧光定量PCR实验(qRT-PCR)检测50例临床肝癌组织及其癌旁正常组织中UBE2T相对表达量;通过转染靶向UBE2T基因的shRNA干扰慢病毒载体GV248-shUBE2T-1,GV248-shUBE2T-2及阴性对照GV248-NC至肝癌HepG2细胞,构建UBE2T基因稳定干扰细胞系,并验证其转染敲降效
High-entropy oxides(HEOs)and medium-entropy oxides(MEOs)are new types of single-phase solid solution materials.MEOs have rarely been reported as positive electrode material for sodium-ion batteries(SIBs).In this study,we first proposed the concept of the
The intrinsic conduction mechanism and optimal sintering atmosphere of(Ba0.85Ca0.15)(Zr0.1Ti0.9)O3(BCZT)ceramics were regulated by Mn-doping element in this work.By Hall and impedance analysis,the undoped BCZT ceramics exhibit a typical n-type conduction
Porous silicon nitride ceramics have attracted a considerable attention due to their excellent overall performance,but poor porosity homogeneity and structural shrinkage induced by prolonged high temperature sintering limit its further application.Herein,
This is the first study to conduct the flash sintering of 3 mol％yttria-stabilized zirconia(3YSZ)ceramics at room temperature(25℃)under a strong electric field,larger than 1 kV/cm.At the standard atmospheric pressure(101 kPa),the probability of successful
Oxidation behaviors of carbon fiber reinforced SiC matrix composites(C/SiC)are one of the most noteworthy properties.For C/SiC,the oxidation behavior was controlled by matrix microcracks caused by the mismatch of coefficients of thermal expansion(CTEs)and
目的 通过检测急性缺血性脑卒中患者血清长链非编码RNA小核仁RNA宿主基因12(long non-coding RNA small nucleolar RNA host gene 12,lncRNA SNHG12)表达变化情况,探究其在急性缺血性脑卒中的临床意义.方法 选取2019年3月～2021年2月秦皇岛市第一医院神经内科收治的95例急性缺血性脑卒中(acute ischemic stroke,AIS)患者作为研究组,根据美国国立卫生研究院卒中量表(National Institute of Heal
High-entropy oxides(HEOs)are widely researched as potential materials for thermal barrier coatings(TBCs).However,the relatively low thermal expansion coefficient(TEC)of those materials severely restricts their practical application.In order to improve the