2011年英国血液病杂志上发表了针对胎儿和新生儿血友病管理的循证指南,如果有证据表明肯定获益或获益将超过损害并值得治疗时则强烈建议(1级);如果获益的程度不是十分确定,则推荐等级为2级。1级建议适用于绝大多数患者,而2级建议在应用时需根据患者具体情况。证据的等级也分 Evidence-Based Guidance for the Management of Hemophilia in Fetus and Neonates, published in the British Journal of Hematology 2011, is strongly recommended (level 1) if there is evidence that positive or beneficial benefits will outweigh the benefits of harm and worth the treatment (level 1); if awarded The degree of benefit is not very sure, then the recommended level is 2. Level 1 recommendations apply to the vast majority of patients, and level 2 recommendations are based on the patient’s specific situation. The level of evidence is also divided