论文部分内容阅读
目的检测 KAI1蛋白和 CD40蛋白在胃癌中的表达情况,并分析其与胃癌的临床病理特征及预后的关系。方法应用免疫组织化学 SP 方法,检测64例胃癌标本中 KAI1蛋白和 CD40蛋白的表达情况。结果在本组胃癌中的 KAI1蛋白阳性表达率为22%。KAI1蛋白的表达与胃癌的分化程度呈正相关,与浸润深度、淋巴结转移和临床分期呈负相关。KAI1蛋白阳性表达的14例中生存期大于5年者10例,占71%,阴性表达的50例中生存期大于5年者10例,占20%,两者之间的差异有统计学意义(χ~2=42.426,P=0.000);CD40蛋白在胃癌组织中的阳性表达率为34%。CD40蛋白阳性表达与胃癌的远处转移及临床分期有关。CD40蛋白阳性表达的22例中生存期大于5年者3例,占14%,阴性表达的42例中生存期大于5年者17例,占41%,两者之间差异有统计学意义(χ~2=4.841,P=0.028)。结论 KAI1蛋白与胃癌的分化、浸润及转移有关;CD40蛋白可能有助于胃癌的转移评估、判断预后和指导治疗。
Objective To detect the expression of KAI1 protein and CD40 protein in gastric cancer and to analyze its relationship with the clinicopathological features and prognosis of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of KAI1 protein and CD40 protein in 64 cases of gastric cancer. Results The positive rate of KAI1 protein in gastric cancer was 22%. The expression of KAI1 protein was positively correlated with the degree of differentiation of gastric cancer and negatively correlated with the depth of invasion, lymph node metastasis and clinical stage. Among the 14 cases with KAI1 positive expression, 10 cases (71%) had survival of more than 5 years and 10 cases (20%) had survival of more than 5 years in 50 cases with negative expression, the difference between the two was statistically significant (χ ~ 2 = 42.426, P = 0.000). The positive rate of CD40 expression in gastric cancer tissues was 34%. The positive expression of CD40 protein is associated with distant metastasis and clinical stage of gastric cancer. Of the 22 cases with CD40 positive expression, those with a survival of more than 5 years were 14% and 42 cases with negative expression were more than 5 years with 17 cases (41%), the difference was statistically significant ( χ ~ 2 = 4.841, P = 0.028). Conclusion The expression of KAI1 protein is related to the differentiation, invasion and metastasis of gastric cancer. CD40 protein may contribute to the metastasis of gastric cancer, prognosis and guidance of treatment.