甲氰眯胍的副作用主要是在胃肠道、造血系统和中枢神经系统方面。本文作者报道1例病人应用甲氰眯胍发生急性肾功能衰竭,并经组织学活检证实为急性问质性肾炎。病人67岁,男性。因发热、寒战、不适及厌食2周入院。过去6年因局限性肠炎一直服用柳氮磺胺毗啶(sulfasaIazine)和强的松,入院时病情稳定。发病前3周因功能性胃肠症状开始应用甲氰咪胍900mg/d。 The side effects of memantine are mainly in the gastrointestinal tract, hematopoietic system and central nervous system. The authors report that 1 patient developed acute renal failure with squinomidine and confirmed by histological biopsy as acute interstitial nephritis. The patient is 67 years old, male. Due to fever, chills, discomfort and anorexia admitted for 2 weeks. For the past six years, heroinconazole had been treated with sulfasaIazine and prednisone for Crohn’s disease and was stable on admission. 3 weeks before onset of functional gastrointestinal symptoms due to the application of cimetidine 900mg / d.