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目的探讨胸中段食管癌三维适形放疗致急性放射性肺炎的临床、物理因素。方法回顾性分析69例胸中段食管癌三维适形放疗患者的相关临床资料,观察性别、年龄、肺病史、吸烟史、合并化疗以及放射物理参数V20、V30、MLD与急性放射性肺炎发生率的关系。结果发生急性放射性肺炎12例,相关因素中基础肺疾病病史、V20、V30、MLD有统计学意义(P<0.05),而性别、年龄、是否吸烟、是否化疗无统计学意义。结论中段食管癌急性放射性肺炎的发生与基础肺疾病史、V20、V30、MLD密切相关,临床制订计划时可以应用以上因素预测急性放射性肺炎。
Objective To investigate the clinical and physical factors of acute radiation pneumonitis caused by three-dimensional conformal radiotherapy in the mid-thoracic esophagus. Methods The clinical data of 69 patients with three-dimensional conformal radiotherapy of thoracic esophageal cancer were retrospectively analyzed. The relationship between sex, age, history of lung disease, smoking history, combined chemotherapy, and radiophysical parameters V20, V30, MLD and the incidence of acute radiation pneumonitis . Results Acute radiation pneumonitis occurred in 12 cases. The related factors including the history of basic lung disease, V20, V30 and MLD were statistically significant (P <0.05), but not sex, age, smoking or whether chemotherapy was statistically significant. Conclusions The incidence of acute radiation pneumonitis in the middle stage of esophageal cancer is closely related to the history of basic lung diseases, V20, V30 and MLD. The above factors may be used in the clinical planning to predict acute radiation pneumonitis.