AIM:To evaluate the impact of time interval for hemofiltration(HF)on the prognosis of severe acute pancreatitis(SAP),METHODS:Thirty-six consecutive patients with severe acutepancreatitis were included in the study.Atlanta classificationsystem was applied for stratification.They were randomlydivided into short veno-venous HF group,(SVVH,Group 1,20 patients);and long veno-venous HF group(LVVH,Group2,16 patients).In group 1,SVVH was stopped when theabdominal signs disappeared,and heart rate and breathrate were less than 90 beats/min and 20 times/min,respectively.HF was stopped if SVVH was continued,andwhen heart rate and breath rate were more than 90 beats/min and 20 times/min again(Group 2).Except that the timeinterval for HF was different,other parameters for HF werethe same.And conservative curing rate,survival rate,costfor hospital stay and length of hospital stay were observed.RESULTS:Time interval for HF in Group 1(3.81±1.3 hr)was shorter than that of in Group 2(9.38±2.9hr),P<0.01.Conservative curing rate(90 %)in Group i was much higherthan that in Group 2(56.3 %)(P<0.05);but cost in Group 1(RMB 56 600±56 400 Yuan)was lower than that in Group 2(RMB 137 000±105 000 Yuan)(P<0.05).And the survival rate(95 %)in Group i was higher than that in Group 2(81.3 %)(P<0.25);however,hospital stay in Group 1(44.3±41 days)was shorter than that in Group 2(55.2±39.5 days)(P<0.2).So,the prognosis was not improved through the prolongationof time interval for HF,but side-effects were seen.CONCLUSION:The prognosis was not further improvedby LVVH in the treatment of SAP,with side-effects.Timeinterval for HF plays an important role in treatment of SAPin early stage.SWH is thought to be superior to LWH;andLVVH is superior to CVVH in early(72hrs)treatment of SAP. AIM: To evaluate the impact of time interval for hemofiltration (HF) on the prognosis of severe acute pancreatitis (SAP), METHODS: Thirty-six consecutive patients with severe acute pancreatitis were included in the study. Atlanta classificationsystem was applied for stratification. They were randomly divided into short veno-venous HF group (SVVH, Group 1, 20 patients); and long veno-venous HF group (LVVH, Group 2, 16 patients) .In group 1, SVVH was stopped when the abdominal signs disappeared, and heart rate and breath rate were less than 90 beats / min and 20 times / min, respectively. HF was stopped if SVVH was continued, and heart rate and breath rate were more than 90 beats / min and 20 times / min again that the time interval for HF was different, other parameters for HF were the same. And conservative curing rate, survival rate, cost for hospital stay and length of hospital stay were observed .RESULTS: Time interval for HF in Group 1 (3.81 ± 1.3 hr) was shorter than that of in Group 2 (9.38 ± 2.9 hr), P <0.01 .Conservative curing rate (90%) in Group i was much higherthan that in Group 2 (56.3%) (P <0.05); but cost in Group 1 (RMB 56600 ± 56 400 Yuan) was lower than that in Group 2 RMB 137 000 ± 105 000 Yuan) (P <0.05) .And the survival rate (95%) in Group i was higher than that in Group 2 (81.3%) (P <0.25); however, hospital stay in Group 1 ( 44.3 ± 41 days) was shorter than that in Group 2 (55.2 ± 39.5 days) (P <0.2) .So, the prognosis was not improved through the prolongationof time interval for HF, but side-effects were seen. CONCLUSION: The prognosis was not further improvedby LVVH in the treatment of SAP, with side-effects. Timeinterval for HF plays an important role in treatment of SAPin early stage. WHH is thought to be superior to LWH; and LVVH is superior to CVVH in early (72hrs) treatment of SAP.