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本方法精密、准确且重演性好。药物制剂中存在的赋形药除黄体酮(Ⅲ)注射剂中的苯甲酸苄酯外,均无干扰。己酸孕酮(Ⅰ)、甲孕酮(Ⅰ)及Ⅲ注射剂测定6次的相对标准偏差分别为1.6,2.5及2.7%。层析柱为30cm×4mm,反相往以μBondapak/CN填充。流动相为30%(Ⅰ为40%)甲醇的0.02M磷酸二氢钾水溶液。室温,流速2ml/分。于UV254nm处检测。内标法定量。Ⅰ～Ⅲ的标准贮备液用乙醇制成1mg/ml,临用时以乙醇或5%乙醇稀释。内标液(Ⅰ为
The method is precise, accurate and repeatable. The excipients present in the pharmaceutical preparations were free from interference except benzyl benzoate in the progestin (III) injections. The relative standard deviations (RSDs) of hexanoate progesterone (Ⅰ), medroxyprogesterone acetate (Ⅰ) and Ⅲ injections were 1.6, 2.5 and 2.7%, respectively. The column was 30cm × 4mm, reversed-phase to μBondapak / CN filled. A mobile phase of 0.02% potassium dihydrogen phosphate in water with 30% (I 40%) methanol. Room temperature, flow rate 2ml / min. Detection at UV254nm. Internal standard method. Ⅰ ~ Ⅲ standard stock solution made of ethanol 1mg / ml, when used with ethanol or 5% ethanol diluted. Internal standard solution (Ⅰ for