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目的:探讨脑钠肽与狼疮性肾炎患者合并心脏损害的关系。方法:选择62例狼疮性肾炎患者和35例健康体检者(对照组),分别行超声心动图检查,测量其左心室舒张末期内径、左心室射血分数、左心室心肌质量指数,同时测定血浆脑钠肽、白蛋白、肌酐等水平;观察脑钠肽与左心室舒张末期内径、左心室射血分数、左心室心肌质量指数、白蛋白、肌酐的关系。结果:狼疮性肾炎组脑钠肽水平明显高于对照组(P<0.01),合并心脏损害的狼疮患者脑钠肽明显高于不合并心脏损害组(P<0.01)。脑钠肽水平与左心室舒张末期内径、左心室心肌质量指数呈正相关(r=0.54,P<0.01;r=0.46,P<0.01);与左心室射血分数呈负相关(r=-0.72,P<0.01)。结论:脑钠肽测定有助于发现并监测狼疮性肾炎合并心脏损害。
Objective: To investigate the relationship between brain natriuretic peptide and heart damage in patients with lupus nephritis. Methods: Sixty-two patients with lupus nephritis and 35 healthy volunteers (control group) were selected. The left ventricular end-diastolic diameter, left ventricular ejection fraction and left ventricular myocardial mass index were measured by echocardiography. Plasma Brain natriuretic peptide, albumin and creatinine. The relationship between brain natriuretic peptide and left ventricular end-diastolic diameter, left ventricular ejection fraction, left ventricular mass index, albumin and creatinine were observed. Results: The level of brain natriuretic peptide in lupus nephritis group was significantly higher than that in the control group (P <0.01). The brain natriuretic peptide in lupus patients with heart damage was significantly higher than that in the group without cardiac damage (P <0.01). Brain natriuretic peptide was positively correlated with left ventricular end-diastolic diameter and left ventricular mass index (r = 0.54, P <0.01; r = 0.46, P <0.01), but negatively correlated with left ventricular ejection fraction , P <0.01). Conclusions: Brain natriuretic peptide assay is useful in detecting and monitoring lupus nephritis with heart damage.