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目的：探讨系统性红斑狼疮（ＳＬＥ）孕妇在ＳＬＥ稳定期外周血中的Ｔ淋巴细胞亚群、自然杀伤细胞（ＮＫ细胞）及可溶性血清白细胞介素－２受体（ＳＩＬ－２Ｒ）的改变。方法：采用流式细胞仪对１４例ＳＬＥ稳定期（仅服用小剂量激素）的患者妊娠时（ＳＬＥ＋ＮＰ组）的Ｔ细胞亚群和ＮＫ细胞进行检测，同时用固相酶联反应法（ＥＬＩＳＡ）检测其ＳＩＬ－２Ｒ。并以１８例稳定期ＳＬＥ未孕妇女（ＳＬＥ组）、２０例正常未孕妇女（ＮＮＰ组）和２０例正常孕妇（ＮＰ组）作对照。结果：ＳＬＥ＋ＮＰ组的辅助性－诱导性Ｔ细胞（ＣＤ４＋）细胞数量较其他３组有明显下降（Ｐ＜０．０１）；ＣＤ４＋／细胞毒性－抑制性Ｔ细胞（ＣＤ８＋）值，ＳＬＥ＋ＮＰ组较ＳＬＥ组和ＮＮＰ组有显著下降（Ｐ＜０．０１），ＮＰ组也有下降，ＳＬＥ＋ＮＰ组和ＮＰ组之间差异无显著性（Ｐ＞０．０５）。ＮＫ细胞数在４组间差异无显著性（Ｐ＞０．０５）；ＳＬＥ＋ＮＰ组ＳＩＬ－２Ｒ有明显增高（Ｐ＜０．０１），其他３组变化不显著（Ｐ＞０．０５）。结论：ＳＩＬ－２Ｒ和ＣＤ４＋细胞数量变化可能对判断稳定期ＳＬＥ孕妇病情进展有重要作用
Objective: To investigate the changes of T lymphocyte subsets, natural killer cells (NK cells) and soluble interleukin-2 receptor (SIL-2R) in peripheral blood of patients with systemic lupus erythematosus (SLE) during stable SLE. Methods: T cell subsets and NK cells during pregnancy (SLE + NP group) were detected by flow cytometry in 14 patients with stable SLE (only taking small dose of hormone). Meanwhile, the enzyme linked immunosorbent assay (ELISA) The SIL-2R was tested. 18 healthy women with SLE (SLE group), 20 normal pregnant women (NNP group) and 20 normal pregnant women (NP group) were used as controls. Results: The numbers of helper-inducible T cells (CD4 +) in SLE + NP group were significantly lower than those in other three groups (P <0.01). The levels of CD4 + / cytotoxic-inhibitory T cells (P <0.01), but also decreased in NP group. There was no significant difference between SLE + NP group and NP group (P> 0.05). There was no significant difference in the number of NK cells between the four groups (P> 0.05). The levels of SIL-2R in SLE + NP group were significantly increased (P <0.01), while those in the other three groups were not significantly different (P> 0.05). Conclusion: The changes of the number of SIL-2R and CD4 + cells may play an important role in judging the progression of SLE in stable stage